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Pharmaceutical compounds are emerging environmental issue due to their continuous input and persistence to aquatic ecosystem even at low trace concentration. The aim of the present review is to find the effective way to reduce the pollutants in the pharmaceutical wastewater. There are several studies in the aim to develop new processes and new technologies to minimize the volume and toxicity of effluents generated by pharmaceutical industry wastewater. It demonstrates that Advanced oxidation process in a system can be a promising technology to treat pharmaceutical wastewater characterized by simultaneous presence of biodegradable and refractory inhibitory compounds.